2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog
  5. Nucleoside Antimetabolite/Analog Inhibitor

Nucleoside Antimetabolite/Analog Inhibitor

Nucleoside Antimetabolite/Analog Inhibitors (51):

Cat. No. Product Name Effect Purity
  • HY-90006
    5-Fluorouracil
    		Inhibitor 99.99%
    5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer. 5-Fluorouracil also inhibits HIV.
  • HY-17026
    Gemcitabine
    		Inhibitor 99.96%
    Gemcitabine (LY 188011) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.
  • HY-15910
    5-BrdU
    		Inhibitor 99.96%
    5-BrdU (BrdU) is a nucleoside analog that competes with thymidine for incorporation into DNA. 5-BrdU is commonly used in the detection of proliferating cells.
  • HY-B0069
    Fludarabine
    		Inhibitor 99.91%
    Fludarabine (NSC 118218) is a DNA synthesis inhibitor and a fluorinated purine analogue with antineoplastic activity in lymphoproliferative malignancies. Fludarabine inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes.
  • HY-B0003
    Gemcitabine hydrochloride
    		Inhibitor 99.93%
    Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.
  • HY-B0016
    Capecitabine
    		Inhibitor 99.99%
    Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase.
  • HY-B0097
    Floxuridine
    		Inhibitor 99.95%
    Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis. Floxuridine has antiviral effects against HSV and CMV.
  • HY-16478
    Trifluridine/tipiracil hydrochloride mixture
    		Inhibitor 99.98%
    Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA.
  • HY-A0005
    Clofarabine
    		Inhibitor 99.88%
    Clofarabine, a nucleoside analogue for research of cancer, is a potent inhibitor of ribonucleotide reductase (IC50=65 nM) by binding to the allosteric site on the regulatory subunit.
  • HY-B0078
    Dacarbazine
    		Inhibitor 99.96%
    Dacarbazine is a nonspecific antineoplastic (antineoplastic) alkylating agent. Dacarbazine inhibits T and B lymphocyte responses with IC50 of 50 and 10 μg/mL, respectively. Dacarbazine can be used in the study of metastatic malignant melanoma.
  • HY-16209
    Forodesine hydrochloride
    		Inhibitor 99.86%
    Forodesine hydrochloride (BCX-1777 hydrochloride) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine hydrochloride is a potent human lymphocyte proliferation inhibitor. Forodesine hydrochloride could induce apoptosis in leukemic cells by increasing the dGTP levels.
  • HY-B0028
    Fludarabine phosphate
    		Inhibitor 99.77%
    Fludarabine (phosphate) is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.
  • HY-10821
    Raltitrexed
    		Inhibitor 99.49%
    Raltitrexed is an antimetabolite agent used in chemotherapy, acting by inhibiting thymidylate synthase.
  • HY-13701
    Nelarabine
    		Inhibitor 99.76%
    Nelarabine (506U78) is a nucleoside analogue and can be used for the research of T cell acute lymphoblastic leukemia (T-ALL).
  • HY-17400
    Tegafur
    		Inhibitor 99.37%
    Tegafur (FT 207; NSC 148958) is a chemotherapeutic 5-FU proagent used in the treatment of cancers; is a component of tegafur-uracil.
  • HY-B0182
    Carmofur
    		Inhibitor 99.95%
    Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC50 of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI).
  • HY-A0063
    Tipiracil hydrochloride
    		Inhibitor 99.91%
    Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.
  • HY-A0063A
    Tipiracil
    		Inhibitor 99.98%
    Tipiracil is a thymidine phosphorylase (TPase) inhibitor.
  • HY-16210
    Forodesine
    		Inhibitor 99.88%
    Forodesine (BCX-1777) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine could induce apoptosis in leukemic cells by increasing the dGTP levels.
  • HY-B0277
    Vidarabine
    		Inhibitor 99.35%
    Vidarabine (Ara-A) an antiviral agent which is active against herpes simplex and varicella zoster viruses. Vidarabine has IC50s of 9.3 μg/ml for HSV-1 and 11.3 μg/ml for HSV-2. Vidarabine also has anti-orthopoxvirus activity.